FIBGEL

Natural injectable Hydrogel For Permanent Implants

FIBGEL™ - COMPONENT FOR MEDICAL DEVICES

FibGel is a biocompatible and safe material for injectable implants composed solely of wood cellulose and water. This nanofibrillated cellulose hydrogel is based on patented technology and is designed and manufactured following ISO 13485 standards in Finland. As a novel hydrogel material, Fibgel is an ideal component for companies developing medical devices for various soft tissue repair and orthopedic applications. 
 

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Benefits of FibGel

 
 
 
 

Biocompatible and safe

Based on the pre-clinical studies, FibGel does not induce immune responses, adverse reactions or a fibrotic capsule around the implant. This ensures safer outcomes for patients and enhances their overall comfort and well-being. Biological safety has been evaluated according to ISO 10993 standards. Nanofibrillated cellulose has been used in class IIb medical devices in clinical use for the past 4 years.

Non-degradable and Long-lasting stability

FibGel is a permanent implant. It remains intact after a single injection, eliminating the need for multiple procedures. This leads to improved patient compliance, reduced healthcare costs, and fewer follow-up visits. 

Customizable for versatile applications

The tunable properties of FibGel allow for adjustable stiffness and the incorporation of additional components, making it highly adaptable to a wide range of medical applications. This flexibility enables tailored solutions that meet specific clinical needs. 

Easy-to-inject

FibGel is easy-to-apply even in high stiffness. Due to its shear thinning properties it can be injected effortlessly even through a fine 25G needle, requiring minimal force. This simplifies the administration process and reduces procedure time. 

Temperature stable for convenient handling

With robust temperature stability, our material can be handled and stored at room temperature , ensuring ease of use and fast preparation. A long shelf life of at least 18 
months ensures reliable performance without the need for special storage conditions, reducing logistical complexities.

Quality controlled

Our nanocellulose is used in class IIb medical device, FibDex wound dressing (fibdex.com). Our sterile material meets the highest quality and safety requirements, providing confidence in its performance and suitability for medical applications also in hydrogel form. 

Animal-free and environmentally sustainable

Composed entirely of wood cellulose and water, our material is pure, inert, and free from animal DNA, aligning with ethical standards and sustainability goals. This commitment to animal-free ingredients supports the development of environmentally friendly and socially responsible biomedical products without any fossil-based materials. FibGel™ is manufactured from renewable and responsibly sourced Finnish birch wood.

            

 
 

Key applications

      • Soft tissue repair
      • Orthopedics
      • Aesthetics
      • Drug delivery
      • Cell transplantation
 

References

  1. Lou Y.-R. et al. The use of Nanofibrillar cellulose hydrogel as a flexible three-dimensional model to culture human pluripotent stem cells, Stem cell and development 2014; Vol. 23:4, pp. 380–392.
  2. Laurén P. et al. Technetium-99m-labeled nanofibrillar cellulose hydrogel for in vivo drug release. Eur J Pharm Sci. 2014 Dec 18;65:79-88.
  3. Koivuniemi R. et al. Clinical Study of Nanofibrillar Cellulose Hydrogel Dressing for Skin Graft Donor Site Treatment. Advances in Wound Care 2020. Vol. 9, No. 4.
  4. Koivunotko E. et al. Cellulase-assisted platelet-rich plasma release from nanofibrillated cellulose hydrogel enhances wound healing. Journal of Controlled Release 2024 Volume 368, pp. 397-412
  5. Chen Y.-J. et al. iPreP is a three-dimensional nanofibrillar cellulose hydrogel platform for long-term ex vivo preservation of human islets. Journal of Clinical Investigation 2019, 4 (21).
  6. Chang H.-T. An engineered three-dimensional stem cell niche in the inner ear by applying a nanofibrillar cellulose hydrogel with a sustained-release neurotrophic factor delivery system. Acta Biomaterialia Volume 108, 2020, pp. 111-127
 
 
UPM Biomedicals launches FibGel™ the world’s first injectable nanocellulose hydrogel for medical devices
News | 10/24/2024 12:00:00 | 4 min

UPM Biomedicals launches FibGel the world’s first injectable nanocellulose hydrogel for medical devices

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