C5aR inhibition of non-immune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2-infected primary human airway epithelia

Posch, W., J. Vosper, A. Noureen, V. Zaderer, C. Witting, G. Bertacchi, R. Gstir, P. A. Filipek, G. K. Bonn, L. A. Huber, R. Bellmann-Weiler, C. Lass-Flörl and D. Wilflingseder (2021). 

Background

Excessive inflammation triggered by a hitherto undescribed mechanism is a hallmark of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and is associated with enhanced pathogenicity and mortality.

 

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Posch, W., J. Vosper, A. Noureen, V. Zaderer, C. Witting, G. Bertacchi, R. Gstir, P. A. Filipek, G. K. Bonn, L. A. Huber, R. Bellmann-Weiler, C. Lass-Flörl and D. Wilflingseder (2021). "C5aR inhibition of non-immune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2-infected primary human airway epithelia." J Allergy Clin Immunol.