Technetium-99m-labeled nanofibrillar cellulose hydrogel for in vivo drug release

Laurén P. et al. 2014

Abstract

"Nanoscale celluloses have recently gained an increasing interest in modern medicine. In this study, we investigated the properties of plant derived nanofibrillar cellulose (NFC) as an injectable drug releasing hydrogel in vivo. We demonstrated a reliable and efficient method of technetium-99m-NFC labeling, which enables us to trace the in vivo localization of the hydrogel. The release and distribution of study compounds from the NFC hydrogel after subcutaneous injection in the pelvic region of BALB/c mice were examined with a multimodality imaging device SPECT/CT. The drug release profiles were simulated by 1-compartmental models of Phoenix® WinNonlin®. The NFC hydrogel remained intact at the injection site during the study. The study compounds are more concentrated at the injection site when administered with the NFC hydrogel compared with saline solutions. In addition, the NFC hydrogel reduced the elimination rate of a large compound, technetium-99m-labeled human serum albumin by 2 folds, but did not alter the release rate of a small compound 123I-β-CIT (a cocaine analogue). In conclusion, the NFC hydrogels is easily prepared and readily injected, and it has potential use as a matrix for controlled release or local delivery of large compounds. The interactions between NFC and specific therapeutic compounds are possible and should be investigated further."

 

Read publication

 

Laurén P. et al. Technetium-99m-labeled nanofibrillar cellulose hydrogel for in vivo drug release. Eur J Pharm Sci. 2014 Dec 18;65:79-88.

Nanofibrillated Cellulose for Skin Substitutes
Story | 2 min

Nanofibrillated Cellulose for Skin Substitutes

Read more
How biomimetic nanofibers advance the realm of cutaneous wound management: The state-of-the-art and future prospects
Story | 2 min

How biomimetic nanofibers advance the realm of cutaneous wound management: The state-of-the-art and future prospects

Read more
Fantastic Event Through Collaboration!
Story | 2 min

Fantastic Event Through Collaboration!

Read more